Anti-IMPDH2 monoclonal antibody (CABT-13959MH)

Mouse anti-Human IMPDH2 monoclonal antibody for WB, IP, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2F23-C7
Species Reactivity
Human
Immunogen
IMPDH2 (AAH12840, 1 a.a. ~ 515 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
IMP (inosine 5"-monophosphate) dehydrogenase 2; IMP (inosine monophosphate) dehydrogenase 2; IMPD2; IMP oxireductase 2; inosine 5" phosphate dehydrogenase 2; IMPD 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IMPDH2 (IMP (Inosine 5-Monophosphate) Dehydrogenase 2) is a Protein Coding gene. Diseases associated with IMPDH2 include retinitis pigmentosa. Among its related pathways are Metabolism and Irinotecan Pathway, Pharmacokinetics. GO annotations related to this gene include RNA binding and oxidoreductase activity. An important paralog of this gene is GMPR2. This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Antigen Description
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5"-monophosphate into xanthine-5"-monophosphate, which is then converted into guanosine-5"-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Mouse monoclonal antibody raised against a full length recombinant IMPDH2. Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Inosine-5-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene. IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. The function about IMPDH2 antigen include IMP dehydrogenase activity; metal ion binding; nucleotide binding; oxidoreductase activity; protein binding.
Pathway
Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, organism-specific biosystem.

Citations


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References


Probst, C; Radzimski, C; et al. Development of a recombinant cell-based indirect immunofluorescence assay (RC-IFA) for the determination of autoantibodies against "rings and rods"-associated inosine-5 '-monophosphate dehydrogenase 2 in viral hepatitis C. CLINICA CHIMICA ACTA 418:91-96(2013).
Seelig, HP; Appelhans, H; et al. Autoantibodies against Inosine-5 '-Monophosphate Dehydrogenase 2-Characteristics and Prevalence in Patients with HCV-Infection. CLINICAL LABORATORY 57:753-765(2011).

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