Anti-GREM2 monoclonal antibody, clone 5E0

Antibody Isotype

IgG2a

Clone

5E0

Species Reactivity

Human

Immunogen

GREM2 (AAH46632, 1 a.a. ~ 169 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

gremlin 2; DAN domain family member 3; CKTSF1B2; FLJ21195; DAND3; Prdc; gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis); Cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog; Protein related to DAN an

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Mouse monoclonal antibody raised against a full-length recombinant GREM2.

Pathway

Signaling by BMP, organism-specific biosystem.