Anti-GREM2 monoclonal antibody (CABT-17586MH)

Mouse anti-Human GREM2 monoclonal antibody for sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5E0
Species Reactivity
Human
Immunogen
GREM2 (AAH46632, 1 a.a. ~ 169 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
gremlin 2; DAN domain family member 3; CKTSF1B2; FLJ21195; DAND3; Prdc
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GREM2 (Gremlin 2, DAN Family BMP Antagonist) is a Protein Coding gene. Diseases associated with GREM2 include accommodative esotropia and norrie disease. Among its related pathways are Signaling by GPCR and Signaling by BMP. GO annotations related to this gene include protein homodimerization activity and heparin binding. An important paralog of this gene is GREM1. This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Antigen Description
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Mouse monoclonal antibody raised against a full-length recombinant GREM2. Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells (By similarity). The function about GREM2 antigen include cytokine activity.
Pathway
Signaling by BMP, organism-specific biosystem.

Citations


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