Anti-GPC1 monoclonal antibody (CABT-20308MH)

Mouse anti-Human GPC1 monoclonal antibody for WB, IF, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
0F0
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein corresponding to full length human GPC1.
Conjugate
Unconjugated

Applications


Application Notes
ELISA (1-5 μg/mL) & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
glypican 1; glypican; FLJ38078; OTTHUMP00000201548; glypican proteoglycan 1; glypican-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GPC1 (Glypican 1) is a Protein Coding gene. Diseases associated with GPC1 include biliary atresia and omodysplasia. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include copper ion binding and fibroblast growth factor binding. An important paralog of this gene is GPC4. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Antigen Description
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Mouse monoclonal antibody raised against full length recombinant GPC1. Note=Associates (via the heparan sulfate side chains) with fibrillar APP-beta amyloid peptides in primitive and classic amyloid plaques and may be involved in the deposition of these senile plaques in the Alzheimer disease (AD) brain (PubMed:15084524). Note=Misprocessing of GPC1 is found in fibroblasts of patients with Niemann-Pick Type C1 disease. This is due to the defective deaminative degradation of heparan sulfate chains (PubMed:16645004). Glypican-1 is a protein that in humans is encoded by the GPC1 gene. The function about GPC1 antigen include heparan sulfate proteoglycan binding.
Pathway
Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Glypican 1 network, organism-specific biosystem; Glypican pathway, organism-specific biosystem; Inactivation of Cdc42 and Rac, organism-specific biosystem; Role of Abl in Robo-Slit signaling, organism-specific biosystem.

Citations


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References


Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
RUSSELL, DA; SACHS, MM; et al. THE MAIZE CYTOSOLIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GENE FAMILY - ORGAN-SPECIFIC EXPRESSION AND GENETIC-ANALYSIS. MOLECULAR & GENERAL GENETICS 229:219-228(1991).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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