Anti-EDNRA monoclonal antibody, clone 3B6

Antibody Isotype

IgG2a

Clone

3B6

Species Reactivity

Human

Immunogen

EDNRA (AAH22511, 18 a.a. ~ 80 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

endothelin receptor type A; OTTHUMP00000220091; Endothelin A receptor; OTTHUMP00000220093; ET-A; endothelin ET-A receptor; ETA; endothelin receptor subtype A; ETA-R; endothelin receptor, ET1-specific type; ETRA; endothelin-1 receptor; hET-AR; endothelin-1

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.
Mouse monoclonal antibody raised against a partial recombinant EDNRA.

Pathway

Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; EGFR-dependent Endothelin signaling events, organism-specific biosystem; Endothelins, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem