Specifications
Immunogen
CXCL11 (AAH05292, 1 a.a. ~ 95 a.a) full-length recombinant protein with GST tag.
Target
Alternative Names
chemokine (C-X-C motif) ligand 11; Small-inducible cytokine B11; H174; IP9; I-TAC; MGC102770; IP-9; OTTHUMP00000219214; SCYB11; beta-R1; SCYB9B; C-X-C motif chemokine 11; b-R1; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys)
Product Background
Antigen Description
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene.
Mouse monoclonal antibody raised against a full-length recombinant CXCL11.
Pathway
CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem
Citations
Publication ()
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COA
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