Anti-C21ORF2 monoclonal antibody (CABT-10321MH)

Mouse anti-Human C21ORF2 monoclonal antibody for sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
2F5
Species Reactivity
Human
Immunogen
C21orf2 (NP_004919, 1 a.a. ~ 102 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
chromosome 21 open reading frame 2; hypothetical protein LOC755; A2; C21orf-HUMF09G8.5; YF5; YF5/A2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
C21orf2 (Chromosome 21 Open Reading Frame 2) is a Protein Coding gene. Diseases associated with C21orf2 include st. louis encephalitis. Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients.
Antigen Description

Mouse monoclonal antibody raised against a partial recombinant C21orf2. May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. The function about C21ORF2 antigen include molecular_function.

Citations


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References


Kahler, CM; Carlson, RW; et al. Inner core biosynthesis of lipooligosaccharide (LOS) in Neisseria meningitidis serogroup B: Identification and role in LOS assembly of the alpha 1,2 N-acetylglucosamine transferase (RfaK). JOURNAL OF BACTERIOLOGY 178:1265-1273(1996).
Boese, A; Sauter, M; et al. Human endogenous retrovirus protein cORF supports cell transformation and associates with the promyelocytic leukemia zinc finger protein. ONCOGENE 19:4328-4336(2000).

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