HTLV type 1 Mosiac (aa 374 - 400, 190 - 207), recombinant protein from E. coli
Recombinant HTLV-I Mosiac
Immunoreactive with all sera of HTLV-I and HTLV-II infected individuals with antibody response to HTLV envelope.
Protein is > 95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC.
1mg/ml in 25mM Tris-HCl, 5mM glutation and 50% glycerol.
2-8°C short term, -20°C long term
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
HTLV-I gp46; Glycoprotein 46; SU; Surface protein; HTLV-I gp46 antigen; glycoprotein 46 protein; gp46 protein; Glycoprotein 46 protein; Deltaretrovirus; Retroviridae; Human T-lymphotropic virus Type I; T-lymphotropic virus Type I Gp46; HTLV-1; Adult T-cel