HSV type 8 Mosaic protein [GST], recombinant protein from E. coli
Recombinant HSV/Herpes Simplex Virus-8 Mosaic, GST-tagged
Immunoreactive with sera of HSV-8 infected individuals.
HSV-8 Mosaic protein is > 95% pure as determined by 10% PAGE (coomassie staining).
100 mM NaCl + 0.1% SDS and 50% glycerol.
2-8°C short term, -20°C long term
Entry of HSV into the host cell involves interactions of several viral glycoproteins with cell surface receptors. The virus particle is covered by an envelope which, when bound to specific receptors on the cell surface, will fuse with the cell membrane and create an opening, or pore, through which the virus enters the host cell. The sequential stages of HSV entry are analagous to those of other viruses. At first, complementary receptors on the virus and cell surface bring the two membranes into proximity. In an intermediate state, the two membranes begin to merge, forming a hemifusion state. Finally, a stable entry pore is formed through which the viral envelope contents are introduced to the host cell.
A mosaic protein or peptide is an artificial recombinant protein designed from a set of reference protein sequences so that every constituent peptide (k-mer) is found some place in the set of input proteins. (For common usage, k-mer lengths correspond to