Methaqualone(4') [HRP]

Name: Methaqualone(4') [HRP]
SKU: DAG1235
Rating: 5 (1 reviews)

Methaqualone(4'), HRP-conjugated, synthetic

COA

SDS

Datasheet

Summary

Product Overview

Methaqualone(4'), HRP conjugate

Target

Methaqualone

Nature

Synthetic

Tag/Conjugate

HRP

Format

Concentrate

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Methaqualone (brand name Quaalude /?kwe?lu?d/) in the USA and Mandrax in the UK is a sedative-hypnotic drug of the quinazolinone class that acts as a general central nervous system depressant. The sedative–hypnotic activity of methaqualone was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in the US by Wallace and Tiernan. Its use peaked in the early 1970s as a hypnotic, for the treatment of insomnia, and as a sedative and muscle relaxant. It has also been produced clandestinely and used illegally as a recreational drug.

Antigen Description

Methaqualone is one of the most potent quinazolines, first synthesized in 1951 and introduced in Europe in 1956. It was marketed in the United States in 1965 as a safe barbiturate substitute, with nonaddictive sedative-hypnotic properties. As early as 1966 there were reports of both physical and psychological dependence. Apart from sedative hypnotic properties methaqualone has anti-convulsant, antispasmodic, anaesthetic and antihistamine actions. When used excessively it leads to tolerance dependence and withdrawal symptoms. As the addictive nature of methaqualone became clear it was withdrawn from many developed markets and was made a schedule I drug in the US in 1984. Since 1973 the oral use of methaqualone as a drug of abuse has decreased dramatically in western countries. However the practice of smoking methaqualone is a serious public health problem in South Africa, other parts of Africa and India. When smoked the methaqualone is combined with cannabis and tobacco in a process called 'white pipe' giving rise to an intensely euphoric rush.

Keywords

Methaqualone; Methaqualone(5)

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Documents

pdf COA

pdf SDS

pdf Datasheet

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Customer Reviews

References

Substance misuse in youth admitted to a psychiatric emergency unit

SOUTH AFRICAN MEDICAL JOURNAL

Authors: Wilson, DAB; Flisher, AJ; Allin, R; Laubscher, JA

Abstract

Objectives. To investigate the pattern of substance misuse in youth admitted to a psychiatric emergency unit of a major hospital, and to compare regular users of cannabis, methaqualone and alcohol with the rest of the-sample in terms of selected psychosocial variables. Study population. Consecutive patients-aged 25 years or younger admitted to a psychiatric emergency unit-over a 3-month period. Method. Patients completed a standardised: questionnaire containing questions about their family, social, economic and educational backgrounds. Their current-psychiatric folder was examined to ascertain mental state and behaviour on admission as well as previous psychiatric contacts and hospitalisation. Particular attention was paid to the use of cannabis, methaqualone and alcohol. For each substance patients were divided into two groups, namely those who did not use the substance or who used it infrequently, and regular users: Unadjusted odds ratios were used to document the relationship between substance use and the selected psychosocial variables. Results. One hundred and fourteen patients were assessed, of which number 61 (53.5%) were male and 98 (86%) were single. The group consisted of 37 blacks (32.5%), 56 coloureds (49.1%) and 21 whites (18.4%).;Alcohol was regularly used by 30 patients (26.3%), cannabis by 29 (25.4%), methaqualone by II (9.6%),and any of these substances by 46 patients (40.4%). :Unadjusted odds ratios showed;hat there was a significant association between regular use of alcohol and cannabis and male:gender, dropping out of School, previous: psychiatric treatment, and an absence of both depression and suicidal ideation; and between regular cannabis use and bizarre behaviour, auditory hallucinations and disorganised or incoherent speech. Methaqualone use was associated with hostile threats. Conclusions. In the study population substance use was associated with various adverse psychosocial circumstances; these may alert the practitioner to the possibility of substance use. Cannabis misuse was suggested by behavioural, perceptual and speech abnormalities on mental state examination.

Exploring the Intersecting Health Risks of Substance Abuse, Sexual Risk, and Violence for Female South African Teen Dropouts

JOURNAL OF PSYCHOLOGY IN AFRICA

Authors: Sawyer-Kurian, Kyla Marie; Browne, Felicia A.; Carney, Tara; Petersen, Petal; Wechsberg, Wendee M.

Abstract

The study sought to better understand the cultural contexts of the risks for adolescent females who have dropped out of school. Focus groups were conducted with 37 Black and Coloured females aged 13 to 17 in Cape Town, South Africa. Data were analysed using content analysis. Methamphetamine, cannabis, and alcohol were used by both, however, Black teens also used methaqualone and Coloured teens used heroin and ecstasy. Some teens traded sex for drugs and others did so at the request of their drug-addicted mothers. Teens revealed high rates of violence, including rape, and many myths and barriers about condom use, revealing risky sex behaviours. Conclusion Cultural nuances between the two groups will help inform the adaptation of an HIV prevention intervention.