MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]
Function
apolipoprotein binding; lipid binding; lipid transporter activity; protein heterodimerization activity;
Synonyms
MTTP; microsomal triglyceride transfer protein; ABL; MTP; microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein (large polypeptide, 88kDa);
Citations
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