This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]
Function
ATP binding; DNA binding; DNA-dependent ATPase activity; NOT damaged DNA binding; mismatched DNA binding; nucleotide binding;
Synonyms
MSH4; mutS homolog 4 (E. coli); mutS (E. coli) homolog 4; mutS protein homolog 4; hMSH4;
Citations
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