Human MLL4 blocking peptide

Name: Human MLL4 blocking peptide
SKU: CDBP1883
Rating: 5 (1 reviews)

Synthetic Human MLL4 blocking peptide for Apuri, BL, ELISA

COA

SDS

Datasheet

Summary

Product Overview

Blocking/Immunizing peptide for anti-MLL4 antibody

Target

MLL4

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

9757

Antigen Description

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]

Function

DNA binding; histone methyltransferase activity (H3-K4 specific); metal ion binding; methyltransferase activity; protein binding; sequence-specific DNA binding transcription factor activity; transferase activity; zinc ion binding;

Synonyms

MLL4; myeloid/lymphoid or mixed-lineage leukemia 4; histone-lysine N-methyltransferase MLL4; KMT2D; WBP-7; trithorax homolog 2; trithorax homologue 2; WW domain binding protein 7; WW domain-binding protein 7; lysine N-methyltransferase 2D; mixed lineage leukemia gene homolog 2; myeloid/lymphoid or mixed-lineage leukemia protein 4; HRX2; MLL2; TRX2; WBP7; KIAA0304;

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

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Customer Reviews

References

The Cell Cycle Regulators CDK4, CDK6 and Cyclin D3 As Well As the Histone Methyltransferases MLL2 and MLL4 Constitute NF-E2 Target Genes That Participate in a Novel Regulatory Loop

BLOOD

Authors: Koellerer, Christoph; Pahl, Heike L.; Wehrle, Julius

Abstract

Roles of Histone H3-Lysine 4 Methyltransferase Complexes in NR-Mediated Gene Transcription

REGULATORY MECHANISMS IN TRANSCRIPTIONAL SIGNALING

Authors: Lee, Seunghee; Roeder, Robert G.; Lee, Jae W.

Abstract

Transcriptional regulation by nuclear hormone receptors (NRs) requires multiple coregulators that modulate chromatin structures by catalyzing a diverse array of posttranslational modifications of histones. Different combinations of these modifications yield dynamic functional outcomes, constituting an epigenetic histone code. This code is inscribed by histone-modifying enzymes and decoded by effector proteins that recognize specific covalent marks. One important modification associated with active chromatin structures is methylation of histone H3-lysine 4 (H3K4). Crucial roles for this modification in NR transactivation have been recently highlighted through our purification and subsequent characterization of a steady-state complex associated with ASC-2, a coactivator of NRs and other transcription factors. This complex, designated ASCOM for ASC-2 complex, contains H3K4-methyltransferase MLL3/HALR or its paralogue MLL4/ALR and represents the first Sett-like H3K4-methyltransferase complex to be reported in vertebrates. This review focuses on recent progress in our understanding of how ASCOM-MLL3 and ASCOM-MLL4 influence NR-mediated gene transcription and of their physiological function.