Human MLH1 peptide

Specificity

Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart.

Nature

Synthetic

Tag/Conjugate

Unconjugated

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Gene ID

4292

UniProt ID

P40692

Antigen Description

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]

Function

ATP binding; ATPase activity; contributes_to MutSalpha complex binding; guanine/thymine mispair binding; protein binding; contributes_to protein binding; contributes_to single-stranded DNA binding;

Synonyms

MLH1; mutL homolog 1; FCC2; COCA2; HNPCC; hMLH1; HNPCC2; DNA mismatch repair protein Mlh1; mutL homolog 1, colon cancer, nonpolyposis type 2;