2-Panel Drug Test (Strip) (MET,THC) (DTS277)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Intended Use
All of DOA Panel Drug Test is an immunochromatography based one step in vitro test. It is designed for qualitative determination of drug substances in human urine specimens. This assay may be used in the point of care setting. Below is a list of cut-off concentrations for each drug using our test.
The test device should be stored at 2 to 30°C and will be effective until the expiration date stated on the package. The product is humidity-sensitive and should be used immediately after being open. Any improperly sealed product should be discarded.
The cut-off concentrations (sensitivity level) of DOA Panel Drug Test are determined to be: AMP 1000 ng/ml, BAR, 300 ng/ml, BZO 300 ng/ml, BUP 10 ng/ml, COC 300 ng/ml, EDDP 100 ng/ml, KET 1000 ng/ml, MTD 300 ng/ml, MET 1000 ng/ml, MDMA 500 ng/ml, OPI 300


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Injectable self-healing supramolecular hydrogels with conductivity and photo-thermal antibacterial activity to enhance complete skin regeneration


Authors: Zhang, Beilin; He, Jiahui; Shi, Mengting; Liang, Yuqing; Guo, Baolin

Hydrogel dressings with good biocompatibility and the ability to maintain a moist environment at the wound site have great potential for clinical application. Multifunctional injectable self-healing supramolecular hydrogel with conductivity and photo-thermal property as wound dressing to promote wound healing has been not reported. Herein, a series of antibacterial, injectable self-healing and conductive supramolecular hydrogels were fabricated through host-guest interaction based on quaternized chitosan-graft-cyclodextrin (QCS-CD), quaternized chitosan-graft-adamantane (QCS-AD) and graphene oxide-graft-cyclodextrin (GO-CD) polymer solutions which combined the good antibacterial activity of QCS and photo-thermal property of reduced graphene oxide (rGO). These supramolecular hydrogels wound dressings have a conductivity value similar to that of the skin and a rapid self-healing behavior, and have great antibacterial property against E. coli (gram-negative), S. aureus (gram-positive), and multi-drug resistant bacteria (such as Methicillin-resistant Staphylococcus aureus, MRSA). Furthermore, QCS-CD-AD/GO4 (0.4 wt% of rGO in the sample) shows a good balance between antibacterial activity, cell proliferation and hemocompatibility. Compared with commercial dressings (Tegaderm (TM) film) and QCS-CD-AD/GO0, the hydrogel QCS-CD-AD/GO4 significantly accelerated the in vivo healing process of full-thickness wounds with promoted epidermis and granulation tissue thickness, increased area coverage of collagen, and up-regulated VEGF expression. In short, these antibacterial, conductive self-healing supramolecular hydrogels are promising biomaterials as wound dressings for full-thickness skin repair.

Fungal infections in humans: the silent crisis


Authors: Kainz, Katharina; Bauer, Maria A.; Madeo, Frank; Carmona-Gutierrez, Didac

Annually, over 150 million severe cases of fungal infections occur worldwide, resulting in approximately 1.7 million deaths per year. Alarmingly, these numbers are continuously on the rise with a number of social and medical developments during the past decades that have abetted the spread of fungal infections. Additionally, the long-term therapeutic application and prophylactic use of antifungal drugs in high-risk patients have promoted the emergence of (multi)drug-resistant fungi, including the extremely virulent strain Candida auris. Hence, fungal infections are already a global threat that is becoming increasingly severe. In this article, we underline the importance of more and effective research to counteract fungal infections and their consequences.

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