Product Overview
Blocking/Immunizing peptide for anti-MEPI/SERPINI2 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Function
peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Synonyms
SERPINI2; serpin peptidase inhibitor, clade I (pancpin), member 2; PI14, serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2 , serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2; serpin I2; MEPI; PANCPIN; pancpin; TSA2004; PI-14; protease inhibitor 14; peptidase inhibitor 14; pancreas-specific protein TSA2004; myoepithelium-derived serine protease inhibitor; serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2; PI14;
Citations
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Chaiworapongsa, T; Romero, R; et al. Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the phenotype of preeclampsiaa. JOURNAL OF PERINATAL MEDICINE 41:485-504(2013).
Loftus, SK; Cannons, JL; et al. Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency. PLOS GENETICS 1:369-379(2005).