General Notes
This product (Catalog No. CABT-BL5133) is a rabbit-derived IgG polyclonal antibody raised against human MCOLN1, targeting the amino acid region 501–580 of the protein. This antibody exhibits cross-reactivity with MCOLN1 from mouse, rat, pig, cow, rabbit, sheep, monkey, and cat. It has been affinity purified by protein A. This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.
CABT-BL5133 is suitable for use in IHC-P (1:100–1:500), IHC-F (1:100–1:500), IF (immunofluorescence) (1:100–1:500), ICC/IF (1:100–1:500), ELISA (1:5,000–1:10,000) applications.
CABT-BL5133 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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