Anti-MCOLN1 (C-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide from the C-terminal region of isoforms 1, 2 of Human Mucolipin 1 conjugated to an immunogenic carrier protein.

Conjugate

Application Notes

WB: 1:300-1:2000
IHC-Fr: 1:300-1:2000

Alternative Names

MCOLN1; mucolipin 1; mucolipin-1; ML4; MLIV; MST080; MSTP080; TRPM L1; TRPML1; MCLN1_HUMAN; Mcoln 1; Mcoln1; MG 2; MG-2; MG2; ML 4; ML4; MLIV; MST080; MSTP080; Mucolipidin; Mucolipin-1; Mucolipin1; TRP ML1; TRPML1; mucolipidin; mucolipidosis type IV protein; MG-2; TRP-ML1; TRPM-L1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.

Pathway

Iron uptake and transport, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Transferrin endocytosis and recycling, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem;