Human MADD blocking peptide (CDBP1806)

Synthetic Human MADD blocking peptide for BL

Product Overview
MADD ( C - term ) peptide ( human )
Target
MADD
Nature
Synthetic
Species Reactivity
Human
Tag/Conjugate
Unconjugated
Procedure
None
Concentration
0.2 mg/ml
Size
50 μg
Buffer
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Preservative
0.02% Sodium Azide
Storage
Upon Receipt - Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.
UniProt ID
Antigen Description
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Function
Rab guanyl-nucleotide exchange factor activity; death receptor binding; guanyl-nucleotide exchange factor activity; protein binding; protein kinase activator activity;
Synonyms
MADD; MAP-kinase activating death domain; MAP kinase-activating death domain protein; DENN; KIAA0358; RAB3GEP; Rab3 GDP/GTP exchange factor; insulinoma glucagonoma clone 20; differentially expressed in normal and neoplastic cells; IG20; FLJ35600; FLJ36300;

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References


Chow, VTK; Lim, KM; et al. The human DENN gene: genomic organization, alternative splicing, and localization to chromosome 11p11.21-p11.22. GENOME 41:543-552(1998).
Brinkman, BMN; Telliez, JB; et al. Engagement of tumor necrosis factor (TNF) receptor 1 leads to ATF-2-and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression. JOURNAL OF BIOLOGICAL CHEMISTRY 274:30882-30886(1999).

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