Synthetic Human MADD blocking peptide for BL
MADD ( C - term ) peptide ( human )
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Upon Receipt - Keep as concentrated solution. Aliquot and store at -20oC or below. Avoid freeze-thaw cycles.
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Rab guanyl-nucleotide exchange factor activity; death receptor binding; guanyl-nucleotide exchange factor activity; protein binding; protein kinase activator activity;
MADD; MAP-kinase activating death domain; MAP kinase-activating death domain protein; DENN; KIAA0358; RAB3GEP; Rab3 GDP/GTP exchange factor; insulinoma glucagonoma clone 20; differentially expressed in normal and neoplastic cells; IG20; FLJ35600; FLJ36300;