A case of cutaneous tuberculosis evolving for 50 years
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE
Authors: Bourlond, F.; Velter, C.; Lipsker, D.
Introduction. - Tuberculosis is an infection caused by Mycobacterium (M.) tuberculosis. It is rare in France. Clinical presentations vary, making demonstration of the cause of M. Tuberculosis difficult and rendering diagnosis and management difficult. Patients and methods. - A 58-year-old man, born in Morocco, consulted for ulceration of the right forefoot that had been present since the age of 3 years. He had previously consulted at several dermatology departments. He had undergone numerous skin biopsies and bacteriological and mycobacteriological cultures but these did not contribute to the diagnosis. Slow extension and oozing were observed over time and resulted in functional disability. Given the evocative clinical aspect and despite further negative screening for mycobacteria, anti-TB quadrotherapy was prescribed and resulted in complete cure of the lesion. Discussion. - This case underscores the difficulty of diagnosing cutaneous tuberculosis. Such a diagnosis must be clinically suspected in the presence of long lasting destructive or verrucous skin lesions that fail to heal, even where cultures are negative, and anti-TB therapy should be putatively prescribed. (c) 2020 Elsevier Masson SAS. All rights reserved.
A study on the relationship between air pollution and pulmonary tuberculosis based on the general additive model in Wulumuqi, China
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Authors: Yang, Jiandong; Zhang, Mengxi; Chen, Yanggui; Ma, Li; Yadikaer, Rayibai; Lu, Yaoqin; Lou, Pengwei; Pu, Yujiao; Xiang, Ran; Rui, Baolin
Objective: This study aimed to explore the impact of atmospheric pollutants on the incidence of tuberculosis (TB), and provide new ideas for the prevention and control of TB in the future. Methods: It explored the relationship between air pollutants and meteorological factors, as well as between air pollutants and heating through Spearman correlation analysis and rank sum test. Additionally, it analyzed the relationship between air pollutants and TB incidence using the general additive model. Statistical analysis results at the p < 0.05 level were considered significant. Results: Three months after exposure to air pollutants (PM2.5, SO2, NO2, and CO) TB incidence increased. However, TB incidence increased 9 months after exposure to PM10. The single pollutant model showed when concentrations of PM2.5, PM10, SO2, NO2, CO, and O-3 increased by 1 mg/m(3) (or 1 mg/m(3)), the number of TB cases increased by 0.09%, 0.08%, 0.58%, 0.42%, 6.9%, and 0.57%, respectively. The optimal multi-pollutant model was a two-factor model (PM10 + NO2). Conclusion: Air pollutants including PM2.5, PM10, SO2, NO2, CO, and O-3 increased the risk of TB. Few studies have been conducted in this area of research, especially regarding the mechanism. The results of this study should contribute to the understanding of TB incidence and prompt additional research. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.