Human LDLR blocking peptide

Product Overview

Blocking peptide for anti-LDL-R antibody

Target

LDL-R

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.

Format

Liquid

Concentration

200 μg/ml

Buffer

PBS containing 0.02% sodium azide

Preservative

0.02% Sodium Azide

Storage

Store at -20℃, stable for one year.

Gene ID

3949

UniProt ID

P01130

Antigen Description

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Function

calcium ion binding; glycoprotein binding; low-density lipoprotein particle binding; low-density lipoprotein receptor activity; protein binding; very-low-density lipoprotein particle receptor activity;

Synonyms

LDLR; low density lipoprotein receptor; FH; FHC; LDLCQ2; low-density lipoprotein receptor; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3;