Human Ku p70, p80 [His], recombinant protein from Baculovirus
Recombinant human Ku (p70/p80), his-tagged
SDS-PAGE; Western blot with i: anti-Ku autoantibody-positive patient sera; ii: monoclonal anti-hexa-His-tag antibody.
0.2-0.6 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
Ku antigen consists of two polypeptides (70 kDa and 80 kDa; the p80 subunit is occasionally called p86). The Ku heterodimer provides DNA-binding and regulatory functions to DNA-dependent protein kinase which is a central enzyme for DNA recombination processes in eucaryotic cells. The Ku protein plays important roles in multiple nuclear processes including DNA repair, V(D)J recombination, telomere maintenance, and the regulation of specific gene transcription. Antibodies to Ku were originally reported in scleroderma-polymyositis overlap syndrome (up to 20% of patients) but have also been detectable in about 20% of patients with primary pulmonary hypertension (as a complication of overlap), in 5-10% of SLE and MCTD patients, and in up to 20% of patients with primary Sj gren syndrome.
Ku (p70/p80); 5'-dRP lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, ATP-dependent DNA helicase II, 70 kDa subunit, CTC box binding fact