This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Function
DNA binding; metal ion binding; protein binding; sequence-specific DNA binding transcription factor activity;
Synonyms
KLF10; Kruppel-like factor 10; EGRA; TIEG; TIEG1; EGR-alpha; Krueppel-like factor 10; early growth response-alpha; zinc finger transcription factor TIEG; TGFB-inducible early growth response protein 1; transforming growth factor-beta-inducible early growth response protein 1;
Citations
Publication ()
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