General Notes
This product (Catalog No. CABT-BL4965) is a rabbit-derived IgG polyclonal antibody raised against human KCNN3, targeting the amino acid region 251–350 of the protein. This antibody exhibits cross-reactivity with KCNN3 from mouse, rat, chicken, dog, pig, cow, horse, rabbit, and sheep. It has been affinity purified by protein A. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CABT-BL4965 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
CABT-BL4965 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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