Rabbit Anti-Human KCNN1 (a.a. 401-500) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human; Rat; Dog; Pig; Cow; Horse; Sheep

Immunogen

KLH conjugated synthetic peptide derived from human KCNN1: 401-500/543

Conjugate

Application Notes

WB: 1:500-2000

General Notes

This product (Catalog No. CABT-BL2017) is a rabbit-derived IgG polyclonal antibody raised against human KCNN1, targeting the amino acid region 401–500 of the protein. This antibody exhibits cross-reactivity with KCNN1 from mouse, rat, dog, pig, cow, horse, and sheep. It has been affinity purified by protein A. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.
CABT-BL2017 is suitable for use in Western blot (WB) (1:500–1:2,000) application.
CABT-BL2017 is supplied as a liquid formulation in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

hSK1; KCa2.1; KCNN 1; KCNN 1; Kcnn1; KCNN1_HUMAN; Potassium intermediate/small conductance calcium activated channel subfamily N member 1; SK; SK1; SKCa 1; SKCA1; Small conductance calcium activated potassium channel protein 1; Small conductance calcium-activated potassium channel protein 1

Entrez Gene ID

UniProt ID