This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]
Function
GTP binding; hydrolase activity, acting on acid anhydrides
Synonyms
IRGM; immunity-related GTPase family, M; IFI1; IRGM1; LRG47; LRG-47; immunity-related GTPase family M protein; LRG-47-like protein; interferon-inducible protein 1; immunity-related GTPase family, M1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog
Citations
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