Anti-IL31RA monoclonal antibody (DMABT-H14044)

Mouse anti-Human IL31RA monoclonal antibody for WB, IHC, sELISA, ELISA, RNAi Knockdown Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
4B20
Species Reactivity
Human
Immunogen
IL31RA (NP_620586, 21 a.a. ~230a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
IL31RA; interleukin 31 receptor A; interleukin-31 receptor subunit alpha; CRL; CRL3; GLM R
Entrez Gene ID
UniProt ID

Product Background


Gene summary
IL31RA (Interleukin 31 Receptor A) is a Protein Coding gene. Diseases associated with IL31RA include amyloidosis, primary localized cutaneous, 2 and primary cutaneous amyloidosis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and cytokine receptor activity. An important paralog of this gene is CSF3R. The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Antigen Description
Amyloidosis, primary localized cutaneous, 2 (PLCA2) [MIM:613955]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Note=The disease is caused by mutations affecting the gene represented in this entry. Interleukin-31 receptor A is a protein that in humans is encoded by the IL31RA gene. 0The function about IL31RA antigen include cytokine binding; cytokine receptor activity; protein kinase binding; receptor activity; transcription coactivator activity.

Citations


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References


Ivanov, VN; Ghandhi, SA; et al. Radiation response and regulation of apoptosis induced by a combination of TRAIL and CHX in cells lacking mitochondrial DNA: A role for NF-kappa B-STAT3-directed gene expression. EXPERIMENTAL CELL RESEARCH 317:1548-1566(2011).

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