Human epididymis protein 4 antigen (>90%)

Nature

Native

Tag/Conjugate

Unconjugated

Alternative Names

Human Epididymis Protein 4; WFDC2 gene; ovarian cancer; tumor marker; HE4

Purity

>90% by SDS-PAGE

Format

Liquid

Concentration

Batch dependent - please inquire should you have specific requirements

Buffer

50 mM Sodium Phosphate, pH 7.4 + 0.2 with 20% Glycerol.

Preservative

None

Storage

Short-term store at -70°C. Aliquot to avoid multiple freeze/thaw cycles.

Antigen Description

Human Epididymis Protein 4(HE4) - is a protein that in humans is encoded by the WFDC2 gene.This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.HE4 is a tumor marker of ovarian cancer, with 80% sensitivity at a cut-off of 150 pmol/L.

Keywords

Human Epididymis Protein 4;WFDC2 gene;ovarian cancer;tumor marker;HE4