Intended Use
Human TACI ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinant TACI in a sandwich ELISA format. Using the ELISA protocol described below, this kit provides sufficient reagents to assay TACI in approximately 1500 ELISA plate wells.
Contents of Kit
1. Capture Antibody
2. Detection Antibody
3. Standard
4. StreptAvidin-HRP
5. TMB Liquid Substrate "Ready to Use"
Storage
See "Reagent Preparation"
General Description
Transmembrane activator & calcium modulator and cyclophilin ligand (CAML) interactor (TACI) is lymphocyte specific member1,2 of the tumor necrosis factor-receptor superfamily3 and is expressed in B-lymphocytes and may act to regulate humoral immunity.4 TACI also serves as a receptor for B-cell activating factor of the TNF family (BAFF) and as a proliferation-inducing ligand (APRIL).5
Citations
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Seijas, ABB; Graziani, S; et al. THE IMPACT OF TACI MUTATIONS: FROM HYPOGAMMAGLOBULINEMIA IN INFANCY TO AUTOIMMUNITY IN ADULTHOOD. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 25:407-414(2012).
Wood, PM; et al. Primary antibody deficiency syndromes. CURRENT OPINION IN HEMATOLOGY 17:356-361(2010).