Human Small Nuclear Ribonucleoprotein, recombinant protein from E. coli
Recombinant HumanU1-snRNP 68/70 kDa protein component of the U1 small nuclear ribonucleoproteinparticle Expressedin E. coli bacterial cells.
purity > 90% (SDS-PAGE)
0.3-0.6μg/ml (depending on the type of ELISA plate and coating buffer). Suitable forbiotinylation and iodination.
Neutralto slightly alkaline pH; due to purification workup under denaturingconditions presence of up to 0.02 % SDS (or similar detergents) may berequired for maintaining solubility.
2-8°C short term, -20°C long term
SNRP70 is an RNA-binding protein that is a specific component of the U1 small nuclear ribonucleoprotein complex and constitutes the major anti-(U1) RNP autoimmune antigen. SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA.
snRNP70 also knownas U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans isencoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoproteinthat associates with U1 spliceosomal RNA, forming part of the spliceosome.
SNRNP70; small nuclear ribonucleoprotein 70kDa (U1); RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K; U1 small nuclear ribonucleoprotein 70 kDa; U1 snRNP 70 kDa;