HIV type 1 P24 [His] (DAG-H10311)

HIV type 1 P24 [His], recombinant protein from E. coli Datasheet

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Nature
Recombinant
Tag/Conjugate
His
Purity
> 90 % as determined by SDS-PAGE
Size
100μg; 200μg
Storage
Store it under sterile conditions at -70 °C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Introduction
Human Immunodeficiency Virus (HIV) can be divided into two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa. HIV-2 is related to viruses found in sooty mangabeys. HIV-1 viruses may be further divided into groups. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Some of the HIV-1 group M subtypes are known to be more virulent or are resistant to different medications. HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses. Gag protein from HIV-1 is a polyprotein, which, during viral maturation, is cleaved to release matrix p17, core p24 and nucleocapsid proteins. Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is dissassembled soon after virion entry. The p24 antigen contains epitopes that prime helper CD4 T-cells, which have been demonstrated to be protective and it can elicit lymphocyte proliferation. p24 is likely to be an integral part of any multicomponent HIV vaccine.
Keywords
Gag-p24; CA; HIV-1 Gag-P24; Human Immunodeficiency Virus-1 Gag-P24; HIV-1; Human Immunodeficiency Virus-1

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