Human Chlamydia pneumoniae IgG EIA Kit (DEIA1726)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Size
96T
Sample
serum, plasma
Species Reactivity
Human
Intended Use
CD's Chlamydia pneumoniae IgG test is developed for the detection of IgG antibodies specific to Chlamydia pneumoniae in human serum or plasma.
The kit is semiquantitative allowing comparison of paired samples. The change of antibody level is an aid for the diagnosis of acute Chlamydia pneumonia infection.
The test is recommended to be run and interpreted in parallel with the CD's Chlamydia pneumoniae IgA and IgM EIA kits.
Contents of Kit
1. MICROSTRIPS, 12 x 8 wells
2. SAMPLE DILUENT, 100 mL
3a. CALIBRATOR (EIU=130), 1.0 mL
3b. BORDERLINE CONTROL, 1.0 mL
3c. POSITIVE CONTROL, 1.0 mL
4. CONJUGATE, 30 mL
5. TMB-SUBSTRATE SOLUTION, 18 mL
6. STOPPING SOLUTION, 25 mL
7. WASHING SOLUTION, 100 mL
INCUBATION COVERS, 2 pcs
REAGENT BASINS, 6 pcs
Storage
Reagents are stored between 2°C and 8°C.
Performance Characteristics
Comparison of the four serological methods for detection of acute C. pneumoniae infection

The study shows that out of the 106 cases that were interpreted as acute infection by at least 2 methods, competitor's EIA 1 misinterpreted 14 cases, competitor's EIA2 9 cases, whereas CD's EIAs only 4 cases.
General Description
Since the description in 1986 of Chlamydia pneumoniae as a pathogen (1) it has become recognized as a common infectious agent all over the world. C. pneumoniae is primarily a respiratory tract pathogen that causes approximately 10-20% of community acquired pneumonia in adults and children, and 10-20% of acute bronchitis in adults (2, 3, 4). It also causes sinusitis, primary pharyngitis, and may trigger for asthma (5). Most of infections with this micro-organism are in fact subclinical and asymptomatic and only rarely cause on overt disease (3). Chronic infection with C. pneumoniae has been suggested as a factor in the development of atherosclerosis (6, 7).
Seroepidemiologic studies (8, 9, 10, 11) in different populations suggest that the seroprevalence increases sharply in young children and adolescence. After adolescence the seroprevalence continues to increase and may achieve almost complete saturation for IgG and IgA-class antibodies in the senescence (11).
To date, most investigations have relied on serologic diagnosis. Early studies have been performed with a complement fixation (CF) test which is genus-specific and is more likely to be positive in initial infection than during reinfection (8). The microimmunofluorescence (MIF) method is species-specific, but requires a skilled interpreter and is not suitable for automation and high volume testing. Those technical problems are avoided with the EIA methods developed by CD, providing easy, fast and objective tests.

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