Human Histidyl-tRNA Synthetase (Jo-1) [His], recombinant protein from Baculovirus
Recombinant human Histidyl-tRNA Synthetase (Jo-1), his-tagged
SDS-PAGE (purity > 90%); Western blot with i: Polymyositis sera; ii: monoclonal anti-hexa-His-tag antibody.
0.2-0.4 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
2-8°C short term, -20°C long term
Histidyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 58 kDa protein is an autoantigen recognized by Jo-1 antibodies which occur in 33% of patients with polymyositis and dermatomyositis. Jo-1 antibodies indicate an increased risk for lung involvement, and the disease tends to take a severe course with poor response to therapy.
histidyl-tRNA synthetase; 4816; Ensembl:ENSG00000170445; FLJ20491; histidine--tRNA ligase, cytoplasmic; HisRS; histidine translase; 18.104.22.168; HARS; HRS; USH3B