HCV type 1a Core Antigen (DAG-P2506)

HCV type 1a Core Antigen (aa 1 - 120), recombinant protein from E. coli Datasheet

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Product Overview
Hepatitis C Virus Hepatitis C Virus Core 1a protein fragment
Nature
Recombinant
Tag/Conjugate
Unconjugated
Molecular Weight
16 kDa including tags
Cellular Localization
Host endoplasmic reticulum membrane; Single-pass membrane protein. Host mitochondrion membrane; Single-pass type I membrane protein. Host lipid droplet. Host cytoplasm. Host nucleus. Secreted
Purity
> 85 % by SDS-PAGE.This antigen is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA.
Format
Liquid
Buffer
pH: 8Constituents: 0.32% Tris HCl, 2.4% Urea, 10% Glycerol
Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. pH: 8Constituents: 0.32% Tris HCl, 2.4% Urea, 10% Glycerol
Introduction
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral protease
Antigen Description
HCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.
Keywords
HCV Core

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