Specificity
Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferatin
Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis.
Function
ATP binding; DNA binding; histone kinase activity (H3-T3 specific); protein binding; protein kinase activity;
Synonyms
GSG2; germ cell associated 2 (haspin); HASPIN; serine/threonine-protein kinase haspin; H-haspin; germ cell-specific gene 2 protein; haploid germ cell-specific nuclear protein kinase;
Citations
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Dai, J; Higgins, JMG; et al. Haspin - A mitotic histone kinase required for metaphase chromosome alignment. CELL CYCLE 4:665-668(2005).
Dai, J; Sullivan, BA; et al. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. DEVELOPMENTAL CELL 11:741-750(2006).