T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]
Function
SH3/SH2 adaptor activity;
Synonyms
HSH2D; hematopoietic SH2 domain containing; hematopoietic SH2 domain-containing protein; ALX; FLJ14886; HSH2; hematopoietic SH2 protein; adaptor in lymphocytes of unknown function X;
Citations
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