Anti-HOXA11 monoclonal antibody (DMABT-H13968)

Mouse anti-Human HOXA11 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
9C9
Species Reactivity
Human
Immunogen
HOXA11 (NP_005514, 60 a.a. ~277a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
HOXA11; homeobox A11; homeo boxB22, HOX1, HOX1I; homeobox protein Hox-A11; homeo box 1I; homeobox protein HOXA11
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HOXA11 (Homeobox A11) is a Protein Coding gene. Diseases associated with HOXA11 include radioulnar synostosis with amegakaryocytic thrombocytopenia and synostosis. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.
Antigen Description
Radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT) [MIM:605432]: The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Note=The disease is caused by mutations affecting the gene represented in this entry. Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. The function about HOXA11 antigen include sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity.
Pathway
Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem.

Citations


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References


Harisis, GN; Lewis, AG; et al. Hoxa-11 maintains cell proliferation in the mouse gubernaculum to facilitate testicular descent. JOURNAL OF PEDIATRIC SURGERY 48:2431-2436(2013).

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