Anti-HLA-DMA monoclonal antibody (DMABT-H13922)

Mouse anti-Human HLA-DMA monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
4G23-G22
Species Reactivity
Human
Immunogen
HLA-DMA (AAH11447,2a.a. ~ 261 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
HLA-DMA; major histocompatibility complex, class II, DM alpha; HLA class II histocompatibility antigen, DM alpha chain; D6S222E; RING6; MHC class II antigen DMA
Entrez Gene ID
UniProt ID

Product Background


Gene summary
HLA-DMA (Major Histocompatibility Complex, Class II, DM Alpha) is a Protein Coding gene. Diseases associated with HLA-DMA include rheumatoid arthritis and systemic lupus erythematosus. Among its related pathways are Immune System and Allograft rejection. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is HLA-DRB5. HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Antigen Description
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. HLA class II histocompatibility antigen, DM alpha chain is a protein that in humans is encoded by the HLA-DMA gene.
Pathway
Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem.

Citations


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References


Sanchez, ML; Katsumata, K; et al. Association of HLA-DM polymorphism with the production of antiphospholipid antibodies. ANNALS OF THE RHEUMATIC DISEASES 63:1645-1648(2004).
DENZIN, LK; ROBBINS, NF; et al. ASSEMBLY AND INTRACELLULAR-TRANSPORT OF HLA-DM AND CORRECTION OF THE CLASS-II ANTIGEN-PROCESSING DEFECT IN T2 CELLS. IMMUNITY 1:595-606(1994).

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