HIV type 1 Integrase protein (aa 9 - 289), recombinant protein from E. coli
HIV1 integrase protein fragment
Strongly reacts with human HIV positive serum
> 95 % by SDS-PAGE.
Preservative: None Constituents: 50% Glycerol, 0.2% Triton-X-100, 1.5M Urea, 25mM Tris HCl, pH 8
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles. Preservative: None Constituents: 50% Glycerol, 0.2% Triton-X-100, 1.5M Urea, 25mM Tris HCl, pH 8
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic
Integrase is an enzyme, a product of the HIV1 Gag/Pol gene; the other two enzymes being reverse transcriptase and protease. The human immunodeficiency virus (HIV-1) uses an enzyme, a so-called integrase, to carry out the integration of its viral DNA into the host chromosome thereby tricking the host cell machinery into making viral proteins. The HIV-1 integrase is a protein of 32 kDa and is composed of three domains. No cellular homologue of HIV integrase has been described, so potential inhibitors to this enzyme could be relatively nontoxic.
HIV; Human Immunodeficiency virus 1; IN; Integrase; HIV1 integrase