HIV type 1 Glycoprotein 41 (DAG-P2668)

HIV type 1 Glycoprotein 41, recombinant protein from E. coli Datasheet

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Product Overview
HIV1 gp41 protein fragment
Nature
Recombinant
Tag/Conjugate
Unconjugated
Bio-activity
Reacts strongly with human HIV positive serum.
Purity
> 95 % by SDS-PAGE.
Format
Liquid
Buffer
Preservative: None Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles. Preservative: None Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic
Antigen Description
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.
Keywords
Env; Env polyprotein; Envelope glycoprotein gp160; Envelope Protein gp120; Glycoprotein 41; GP120; gp41; Human Immunodeficiency Virus 1; Human Immunodeficiency Virus Type 1 gp41; TM; Transmembrane protein; HIV1 gp41

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