HIV TAT (aa 1 - 188) (mutation C31 A, C34 A), recombinant protein from E. coli
HIV tat (mutated C31 A + C34 A) full length protein
> 90 % by SDS-PAGE.
Constituent: 0.1% Glycerol
Store at -80°C Constituent: 0.1% Glycerol
DAG-P2159 should be reconstituted in apirogenic sterile water or PBS buffer. Reconstituted protein should be used immediately.
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic
The transcriptional transactivator (Tat) is a key regulatory protein of HIV. It is expressed early after the virus integrates into the cell, and stimulates the elongation of RNA polymerase II. It binds onto a sequence known as the TAR, or transactivator response element, located at the end of the HIV genetic chain. There, the tat protein helps assemble new copies of HIV. The tat protein-TAR complex speeds up the rate of viral reproduction by about a thousand times. If it is not present, the transcription process frequently stops short, and few functional HIV particles are produced. Tat is an important potential target for antiretrovirals and vaccine development.
p14; Tat; Tat protein; Transactivating regulatory protein; HIV TAT