HIV Glycoprotein 41 (DAG-P2670)

HIV Glycoprotein 41, recombinant protein from E. coli Datasheet

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Product Overview
HIV gp41 L protein fragment
Nature
Recombinant
Tag/Conjugate
Unconjugated
Cellular Localization
Cell membrane
Format
Liquid
Buffer
Preservative: 0.01% Sodium Azide Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. Preservative: 0.01% Sodium Azide Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA
Introduction
The human immunodeficiency virus (HIV) is a lentivirus (slowly replicating retrovirus) that causes the acquired immunodeficiency syndrome (AIDS), a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic
Antigen Description
The transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
Keywords
env; Glycoprotein 41; gp41; TM; Transmembrane protein; HIV gp41 L

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