This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]
Function
Rac GTPase activator activity; protein binding; protein complex binding; protein kinase activator activity;
Synonyms
NCKAP1L; NCK-associated protein 1-like; HEM1, hematopoietic protein 1; nck-associated protein 1-like; hematopoietic protein 1; membrane-associated protein hem-1; HEM1;
Citations
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