Blocking peptide for anti-HAAO antibody

HAAO

Synthetic

Human

Unconjugated

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not suitable for human or animal consumption.

Liquid

200 μg/ml

50 μg

PBS containing 0.02% sodium azide

Store at -20^oC, stable for one year.

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

3-hydroxyanthranilate 3,4-dioxygenase activity; 3-hydroxyanthranilate 3,4-dioxygenase activity; electron carrier activity; ferrous iron binding; metal ion binding; oxidoreductase activity; oxygen binding;

HAAO; 3-hydroxyanthranilate 3,4-dioxygenase; HAD; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; HAO; 3-HAO;