Anti-H2AFV monoclonal antibody (DMABT-H13855)

Mouse anti-Human H2AFV monoclonal antibody for IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3G0
Species Reactivity
Human
Immunogen
H2AFV (AAH00098,2a.a. ~ 128 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
H2AFV; H2A histone family, member V; H2AV; histone H2A.V; MGC1947; MGC10170
Entrez Gene ID
UniProt ID

Product Background


Gene summary
H2AFV (H2A Histone Family Member V) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2AFZ. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene.
Antigen Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). Histone H2A. V is a protein that in humans is encoded by the H2AFV gene. 0The function about H2AFV antigen include DNA binding.
Pathway
Systemic lupus erythematosus, organism-specific biosystem; Systemic lupus erythematosus, conserved biosystem.

Citations


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References


Kwon, YS; Chung, JH; et al. Variable region genes of human monoclonal autoantibodies to histones H2A and H2B from a systemic lupus erythematosus patient. MOLECULAR IMMUNOLOGY 42:311-317(2005).

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