Glargine ELISA Kit (DEIABL229)

Regulatory status: For research use only, not for use in diagnostic procedures.

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Size
2x96T
Sample
serum, plasma
Species Reactivity
human
Intended Use
The Glargine ELISA kit is a solid phase two-site enzyme immunoassay. The assay is designed to measure glargine with high specificity and enhanced sensitivity in serum or plasma.
Storage
Store the unopened kit at 2-8°C.
Precision
Intra-assay precision (CV%): 3% - 6%. Inter-assay precision (CV%): 9%.
Detection Limit
4.3 μU/mL

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References


Nocturnal Hypoglycemia with Insulin Degludec and Glargine U100 in Patients with Type 1 Diabetes Prone to Severe Nocturnal Hypoglycemia (HypoDeg): A CGM Substudy

DIABETES

Authors: Brosen, Julie M.; Agesen, Rikke M.; Alibegovic, Amra Ciric; Andersen, Henrik U.; Gustenhoff, Peter; Hansen, Troels K.; Jensen, Tonny, Sr.; Juhl, Claus B.; Lerche, Susanne; Norgaard, Kirsten; Parving, Hans-Henrik D.; Tarnow, Lise; Thorsteinsson, Birger; Pedersen-Bjergaard, Ulrik

Dulaglutide is an effective treatment for lowering HbA1c in patients with type 2 diabetes regardless of body mass index

DIABETES OBESITY & METABOLISM

Authors: Gentilella, Raffaella; Sesti, Giorgio; Vazquez, Luis; Sapin, Helene; Reed, Victoria; Romera, Irene; Pozzilli, Paolo

Aim To assess the relationship between baseline body mass index (BMI) and glycaemic control in dulaglutide-treated patients, a post hoc analysis was conducted on HbA1c and baseline BMI data from eight AWARD studies, with a total of 5770 patients. Materials and methods Changes from baseline in HbA1c data from patients treated with 1.5 mg or 0.75 mg dulaglutide, active comparator or placebo, were analyzed in each study (AWARD-1 to -6, -8 and - 9) at approximately 6 months (26, 24 and 28 weeks, respectively). Within each study, data were analyzed by the following baseline BMI categories: <30, >= 30 to <35, and >= 35 kg/m(2). Results In this post hoc analysis, 1.5 mg or 0.75 mg dulaglutide treatment achieved statistically significant HbA1c reductions from baseline in all BMI categories (least-squares mean change from -0.62 to -1.75%) across the AWARD studies. No statistically significant treatment-by-BMI category interactions were found for reductions in HbA1c. Conclusion This post hoc analysis of eight AWARD studies indicates that baseline BMI does not affect the relative treatment efficacy of dulaglutide as measured by HbA1c change from baseline in any study. Dulaglutide is an effective treatment option for adult patients with type 2 diabetes regardless of their baseline BMI category.

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