This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this genes role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2011]
Function
DNA binding; metal ion binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
Synonyms
GMEB1; glucocorticoid modulatory element binding protein 1; PIF96; P96PIF; glucocorticoid modulatory element-binding protein 1; GMEB-1; PIF p96; DNA-binding protein p96PIF; parvovirus initiation factor p96;
Citations
Publication ()
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