Anti-GMEB1 monoclonal antibody (DMABT-H13834)

Mouse anti-Human GMEB1 monoclonal antibody for WB, IHC, IF, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
3B9
Species Reactivity
Human
Immunogen
GMEB1 (NP_077808, 467 a.a. ~ 563 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
GMEB1; glucocorticoid modulatory element binding protein 1; glucocorticoid modulatory element-binding protein 1; P96PIF; PIF96; GMEB-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
GMEB1 (Glucocorticoid Modulatory Element Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is GMEB2. This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist.
Antigen Description
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene. This gene is a member of KDWK gene family. The product of this gene associates with GMEB2 protein, and the complex is essential for parvovirus DNA replication. Study of rat homolog implicates the role of this gene in modulation of transactivation by the glucocorticoid receptor bound to glucocorticoid response elements. Two alternative spliced transcript variants encoding different isoforms exist. The function about GMEB1 antigen include DNA binding; binding; metal ion binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity.

Citations


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References


Theriault, JR; Charette, SJ; et al. Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein. FEBS LETTERS 452:170-176(1999).

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