Human Glomerular Basement Membrane [His] (DAG4881)

Human Glomerular Basement Membrane [His], recombinant protein from Baculovirus Datasheet

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Product Overview
Recombinant human Glomerular Basement Membrane, his-tagged
Nature
Recombinant
Tag/Conjugate
His
Purity
SDS-PAGE; Western blot with i: Goodpasture patient sera; ii: monoclonal anti-hexa-His-tag antibody.
Concentration
0.12-0.5 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for labeling of functional groups.
Storage
2-8°C short term, -20°C long term
Antigen Description
Antibodies to GBM can cause glomerulonephritis or pulmonary hemorrhage; the combination of these 2 clinical symptoms is known as Goodpasture's syndrome. The best known autoantigen in anti-GBM nephritis is the so-called Goodpasture antigen.
In 1984, the antigen was biochemically characterized and shown to be a 29 kDa collagenase-resistant molecule of the glomerular basement membrane. The important epitope is at the C-terminal end of type IV collagen and was later shown to be localized to the NC1 domain of the α3(IV) chain.
Keywords
GBM; GBM Antigen;

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