Product Overview
Blocking/Immunizing peptide for anti-FXR1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.
Function
G-quadruplex RNA binding; RNA binding; mRNA 3-UTR binding;
Synonyms
FXR1; fragile X mental retardation, autosomal homolog 1; fragile X mental retardation syndrome-related protein 1; hFXR1p; FXR1P;
Citations
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Bakker, CE; Otero, YD; et al. Immunocytochemical and biochemical characterization of FMRP, FXR1P, and FXR2P in the mouse. EXPERIMENTAL CELL RESEARCH 258:162-170(2000).
Bolivar, J; Guelman, S; et al. The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 273:17122-17127(1998).