Mouse anti-Human FOXA2 monoclonal antibody for WB, IHC, sELISA, ELISA
FOXA2 (Forkhead Box A2) is a Protein Coding gene. Diseases associated with FOXA2 include meckels diverticulum and maturity-onset diabetes of the young. Among its related pathways are FOXA2 and FOXA3 transcription factor networks and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is FOXE3. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. The function about FOXA2 antigen include DNA binding; DNA binding, bending; RNA polymerase II core promoter proximal region sequence-specific DNA binding; SMAD binding; double-stranded DNA binding; protein domain specific binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; transcription factor binding; transcription regulatory region DNA binding.
Developmental Biology, organism-specific biosystem; FOXA transcription factor networks, organism-specific biosystem; FOXA1 transcription factor network, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Heart Development, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem.
Katoh, M; Katoh, M; et al. Integrative genomic analyses of CXCR4: Transcriptional regulation of CXCR4 based on TGF beta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors. INTERNATIONAL JOURNAL OF ONCOLOGY 36:415-420(2010).
Rubins, NE; Friedman, JR; et al. Transcriptional networks in the liver: Hepatocyte nuclear factor 6 function is largely independent of Foxa2. MOLECULAR AND CELLULAR BIOLOGY 25:7069-7077(2005).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.